---
title: Variant Validation with VarSome
description: Validate and interpret unclear variant calls in your NGS data, with VarSome Clinical's automated ACMG and AMP classifications leveraging over 100 databases.
image: https://landing.varsome.com/hubfs/Variant%20Validation.jpg
---
[](https://varsome.com/)
- Editions
- [More about VarSome.com](https://varsome.com/varsome-editions/varsome/)
- [More about VarSome Premium](https://varsome.com/varsome-editions/varsome-premium/)
- [More about VarSome Clinical](https://varsome.com/varsome-editions/varsome-clinical/)
- [Learn more about APIs](https://varsome.com/information/varsome-api-info/)
- About
- Resources
- [Library](https://varsome.com/library/)
- [Documentation](https://docs.varsome.com/)
- [Query types](https://varsome.com/about/examples/)
- [IVDR](https://landing.varsome.com/ivdr-whitepaper)
- [Germline Classification](https://varsome.com/about/resources/acmg-implementation/)
- [Somatic Classification](https://varsome.com/about/resources/amp-implementation/)
- Partners
- [Distributors](https://varsome.com/distributors/)
- [Partners](https://varsome.com/partners/)
- [Become a partner](https://landing.varsome.com/become-varsome-partner)
- General
- [The Company](https://saphetor.com/about/)
- [Cite VarSome](https://varsome.com/about/varsome-citations/)
- [Link to VarSome](https://varsome.com/how-do-i-create-link-varsome/)
- [Contact](https://landing.varsome.com/contact)
- [Community](https://varsome.com/community-contributions/)
- [Blog](https://blog.varsome.com/)
[Sign in](https://varsome.com/sign-in/) [Join](https://varsome.com/sign-up/)
WHITEPAPER
# Variant Validation with VarSome
No matter how good your clinical NGS pipeline is, you can still find yourself trying to validate an unclear variant. While you can validate it through Sanger sequencing, a much faster and cheaper alternative is variant calling orthogonal validation. VarSome Clinical is ideally suited to being your variant validation and interpretation pipeline.
- Customized [ACMG](https://landing.varsome.com/implementation-of-acmg-guidelines-whitepaper) and [AMP](https://landing.varsome.com/implementation-of-amp-guidelines) Classification
- Over [100 aggregated and integrated databases](https://varsome.com/datasources/)
- Cited in over 1 000 scientific papers
- Supported by a global community of over 300 000 users
[](https://cta-redirect.hubspot.com/cta/redirect/4384097/30be68de-bc43-45f8-9941-edf6751f8c44)
### Variant Validation with VarSome
[](https://cta-redirect.hubspot.com/cta/redirect/4384097/30be68de-bc43-45f8-9941-edf6751f8c44)
## Customizable Classification
[VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/) allows you to modify the default classification verdict by activating/inactivating specific rules according to your best knowledge.
## Reclassifications and Custom Classifications
In addition to the automatic ACMG and AMP classification offered by [VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/), you have various options to build your own private database of classifications according to your patient's history.
## Periodic Reclassification
Continuous contributions from the VarSome Global Community or novel scientific data may lead to the update of certain variants' annotation. With the regular re-annotation of your past analyses in [VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/), you can locate variants with an updated verdict, reflecting the most recent scientific knowledge which was not available at the time of the initial analysis.
## Variant Comments
You can add comments to specific variants and choose whether you will share them with the global VarSome community or keep them private. Our platform provides several ways to share your experience and benefit from global knowledge with the purpose of increasing the diagnostic yield!
## Sample Cross-referencing
All your samples in [VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/) are linked in the variant level, enabling you to compare current and past cases with great ease.
## Optional Data Sharing
Our platform has patient confidentiality and data protection as a top priority and security procedures are continuously monitored. You can always review all actions of your group’s users in the Audit Trail. Finally, sharing your data with partner institutions processed in [VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/)is entirely your own choice and requires written consent from both parties.
###### Interested in our Solutions?
## Get in touch for a demo and consultation
Loading...
## Latest News
[See all blog posts](https://blog.varsome.com)
- VarSome Suite
- [VarSome.com](https://saphetor.com/varsome-editions/varsome/)
- [VarSome Premium](https://saphetor.com/varsome-editions/varsome-premium/)
- [VarSome Clinical](https://saphetor.com/varsome-editions/varsome-clinical/)
- [VarSome API](https://varsome.com/information/varsome-api-info/)
- System Status
- [System Status](http://status.saphetor.com/)
- Resources
- [Query Examples](https://varsome.com/about/examples/)
- [Documentation](https://docs.varsome.com/)
- [Help Center](https://docs.varsome.com/en)
- [Cite VarSome](https://news.varsome.com/en/cite-varsome-the-human-genomic-variant-search-engine)
- The Company
- [About Saphetor SA](https://saphetor.com/about/)
- [News](https://blog.varsome.com)
- [Distributors](https://landing.varsome.com/distributors)
- [Contact](https://saphetor.com/contact/)
- Legal
- [Terms of Use](https://varsome.com/terms/)
- [Privacy Policy](https://varsome.com/privacy/)
VarSome Suite is brought to you by [Saphetor SA](https://saphetor.com).
© 2024 Saphetor SA – All Rights Reserved.