--- title: VarSome.com description: VarSome is a community-driven project for sharing global expertise on human variants. Our cross-referenced knowledge base integrates more than 140 genomic data sources, with input from over 500,000 users worldwide. --- [Skip to content](https://landing.varsome.com/varsome#main-content) [![VarSome logo white txts](https://landing.varsome.com/hs-fs/hubfs/VarSome%20logo%20white%20txts.png?width=160&height=40&name=VarSome%20logo%20white%20txts.png)](https://sso.varsome.com/) - Editions Show submenu for Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About Show submenu for About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources Show submenu for Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog Show submenu for Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) Open main navigation Close main navigation - Editions Show submenu for Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About Show submenu for About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources Show submenu for Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog Show submenu for Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) - [Sign In](https://varsome.com/) [Sign In](https://varsome.com/) ![varsome-100](https://landing.varsome.com/hubfs/varsome%20logos/varsome-100.png "varsome-100") VarSome is a community-driven project for sharing global expertise on human variants. Our cross-referenced knowledge base integrates more than 150 genomic data sources, with input from over 500 000 users worldwide. ![Copy of VPREM Trial Anno](https://landing.varsome.com/hubfs/Copy%20of%20VPREM%20Trial%20Anno.png "Copy of VPREM Trial Anno") [![Try it For Free](https://no-cache.hubspot.com/cta/default/4384097/interactive-193382884924.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLIEmyFAzVUulHRrtlIMdKoqYoatzPWSiopmi%2BrjTykA%2BH6QwsHNUTjDPHT%2BETSK1oIAJurdeWZD4AzfcOJS6C4yQXL6kaP%2FVDg3Z4GF6efZCVB7uCMXsOjq%2F%2FMrxJ4lIjqgWt9dMs0%2FAI7LxcT2N%2BWXYelm5w%3D%3D&webInteractiveContentId=193382884924&portalId=4384097) [![Built by Saphetor](https://no-cache.hubspot.com/cta/default/4384097/interactive-193385072927.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLK1b0tFKyN2LUBjFHG0JZWHccqi41bUNxLCZvC8JcuTdu%2FtBQNTJ4qZcU1JupsLO011rPRyJYgkX2YxMZy8UEtIeNqXK17tQ8FKSmvElbR8%2BSkDgVv9snMAvZLfpzqX5etwz0ESCR15pS4z%2F9XUL9feecB4bkhE8w%3D%3D&webInteractiveContentId=193385072927&portalId=4384097) Our Solutions VarSome brings together a powerful set of tools for variant annotation, classification, and interpretation, designed for both research and clinical use. Whether you’re exploring individual variants, managing diagnostic workflows, or scaling up with programmatic access, each product is powered by the same high-performance annotation engine and continuously updated knowledge base. ![1-Jul-24-2025-04-54-54-8056-PM](https://landing.varsome.com/hubfs/1-Jul-24-2025-04-54-54-8056-PM.png "1-Jul-24-2025-04-54-54-8056-PM") VarSome Premium is a professional genomic variant search and interpretation tool. It provides access to an extensive database of curated public and proprietary resources, literature, population frequencies, and *in silico* predictions. It supports SNV, indel, CNV, and structural variant interpretation with customisable automated ACMG/AMP-based classifications. [![Start Searching](https://no-cache.hubspot.com/cta/default/4384097/interactive-193382885295.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLLxqLBWsFmQmzlg5zCPerkQ2UXhsVmeEER7sKRjBzHUj9L3OPWk%2Btdzu3Wq82Z%2Fiqlqu6oe2XpytAvg9w8ix653DUSTtWstrQzLN%2F%2BrGqxP0mtz%2BH8OqWlxJBlrKjsZQ1PV3MZhnnMkN6xwuUHodmMqbdYC%2Fj%2FfYrR0i%2Bg8DLQNE%2BgqoHH0wrJ%2B%2FnYEEQ8%3D&webInteractiveContentId=193382885295&portalId=4384097) ![VCLIN Dark 400x50 C](https://landing.varsome.com/hubfs/VCLIN%20Dark%20400x50%20C.png "VCLIN Dark 400x50 C") VarSome Clinical is a CE-IVDR Class C platform for clinical genetic testing workflows. It offers automated variant annotation and classification, supports germline and somatic pipelines, and offers various dynamic and algorithmic filters. Designed for diagnostics labs, it includes collaborative features, custom report templates, and deployment flexibility. [![Start Analyzing](https://no-cache.hubspot.com/cta/default/4384097/interactive-193382885292.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLKz0Ng2Nh57SFZRzfKB5X%2BUMKDo1wLFu916BcBHPsGrEtAt6fK8VdNk9plZeb%2Fo6z6i1qePDDT3gdhs1rckqHu8ZKVwfWJmErGC2%2FLOM5avnOyHkDGhZzqahHIw3hVcLu3hoi7bRXjkNdNSC7eKx50EWc3qytYOMfaTjjiRoQJ77cWGZoEi08cE0Q%2BS5ZWv&webInteractiveContentId=193382885292&portalId=4384097) ![3-Jul-24-2025-04-54-54-7356-PM](https://landing.varsome.com/hubfs/3-Jul-24-2025-04-54-54-7356-PM.png "3-Jul-24-2025-04-54-54-7356-PM") The VarSome API enables programmatic access to VarSome’s annotation engine. It supports high-throughput variant processing, returns ACMG/AMP-based classifications, and includes batch annotation and filtering tools. Designed for integration into bioinformatics pipelines, LIMS, or custom software, it offers scalable performance and flexible pricing options. [![Start Coding](https://no-cache.hubspot.com/cta/default/4384097/interactive-193382885276.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLIM1YAzh4PeLS8o3%2F7nruU0LdPl4ZkTGmfnC7m9avAcG1qLonB7ZPAjcIxxgXzKhwoMH%2FeqyD5r1LWBlRsapWLlpAKL%2BQz2grt7uzWVlupE26Q627CnMrdkLFPXK%2FwpcSme%2FDbZG19rtAiZACwbGVhIwVBB%2F%2BV20dIg4ZHXXQO6NjCDhjPlxLowkA%3D%3D&webInteractiveContentId=193382885276&portalId=4384097) Our Mission VarSome aims to empower researchers, clinicians, and bioinformaticians to interpret genetic data with clarity, consistency, and confidence. By combining comprehensive variant annotation, standard-based classification, and collaborative features, our tools help users find, share, and apply genomic knowledge to support better decisions, drive discovery, and improve health outcomes worldwide. Why VarSome? ## VarSome.com VarSome.com is a **free search engine and community platform** **for exploring human genetic variants**. It provides access to curated data, interpretation support based on ACMG guidelines, and user-contributed insights, helping researchers and clinicians make sense of complex genomic information. We apply usage limits to keep VarSome responsive for the whole community. Registered users can run up to 30 queries per hour or 100 per day. [Premium subscribers](https://landing.varsome.com/varsome-premium) get priority access, so searches, annotations, and analysis run immediately, even during peak demand. For more information, please see our **[Terms of Use.](https://varsome.com/information/legal/terms/?hsCtaAttrib=193120087971)** ## Global Community **Join our worldwide community of over 500 000 healthcare and life sciences professionals,** who classify, link research findings and publications, and share evidence on variants. VarSome also helps introduce users who wish to exchange notes on search results, without compromising the strict privacy policies of both parties. ## Comprehensive Genomic Data Coverage VarSome offers **a massive cross-referenced knowledge base** **of 140+ data sources,** representing over 33 billion data points. We regularly update our databases to make sure the annotations and classifications we share are up-to-date. ## Automated Variant Classification VarSome.com provides **automated germline variant classification** based on the guidelines of the *American College of Medical Genetics and Genomics* (Richards et al. 2015). Each rule is explained, showing why it has or has not been triggered. Users can turn on and off rules to adjust for their own evidence and truly interrogate the classification. [VarSome Premium](https://landing.varsome.com/varsome-premium)supports both **germline and somatic classification, based on ACMG/AMP guidelines.** [VarSome Clinical](https://landing.varsome.com/varsome-clinical)includes all Premium features and adds further flexibility. Users can apply ACMG-based classification to CNVs, import preferred transcripts, and integrate local population databases for **customised annotation and classification.** ## Versatile Variant Search You can search VarSome by **HGVS nomenclature, rsID, gene name, transcript symbol, or genomic location.** VarSome can also parse single lines from VCF files to find the variant they describe. The results are not limited to known variants; you can query any possible variant. With [VarSome Clinical](https://landing.varsome.com/varsome-clinical), you can **annotate entire VCF and FASTQ files** and generate a clinical report for your NGS data. ## Full Text Search With VarSome full-text search, you can **query our knowledge base with plain text descriptions**, making it easy to find what you're looking for. It allows you toperform targeted searches of the entire contents of VarSome, to find **articles, diseases, phenotypes, genes, and more.** ## Application Programming Interface (API) [VarSome's API](https://landing.varsome.com/varsome-api) gives you **direct access to our interpretation engine**, combining rich data integration with fast, flexible annotation. Designed to work with your existing workflow, it simplifies **variant analysis at scale,** without the overhead of managing multiple data sources. Mentioned 5000+ Times in Literature Here are a few of our favorites! ## Benchmarking of variant calling software for whole-exome sequencing using gold standard datasets - [Wong et al. 2025.](https://doi.org/10.1038/s41598-025-97047-7) ## Reinterpretation of Conflicting ClinVar BRCA1 Missense Variants Using VarSome and CanVIG-UK Gene-Specific Guidance - [So et al. 2024.](https://doi.org/10.3390/diagnostics14242821) ## Integration of VarSome API in an existing bioinformatic pipeline for automated ACMG interpretation of clinical variants - [Sorrentino et al. 2021.](https://www.europeanreview.org/wp/wp-content/uploads/1-6.pdf) ## Want to read more? [Click here](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22varsome%22&oq=%22) for the list of publications. ## Cite VarSome! If you use VarSome for your work, please cite our paper below: VarSome: The Human Genomic Variant Search Engine. Christos Kopanos, Vasilis Tsiolkas, Alexandros Kouris, Charles E Chapple, Monica Albarca Aguilera, Richard Meyer, and Andreas Massouras. Oxford Bioinformatics, bty897, 30 October 2018. **doi: **https://doi.org/10.1093/bioinformatics/bty897 x ##### Get the latest from genomics and VarSome in your inbox, every month. ### Subscribe to our monthly newsletter! 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