VarSome.com is a free search engine and community platform for exploring human genetic variants. It provides access to curated data, interpretation support based on ACMG guidelines, and user-contributed insights, helping researchers and clinicians make sense of complex genomic information.

We apply usage limits to keep VarSome responsive for the whole community. Registered users can run up to 30 queries per hour or 100 per day. Premium subscribers get priority access, so searches, annotations, and analysis run immediately, even during peak demand. For more information, please see our Terms of Use.

Join our worldwide community of over 500 000 healthcare and life sciences professionals, who classify, link research findings and publications, and share evidence on variants. VarSome also helps introduce users who wish to exchange notes on search results, without compromising the strict privacy policies of both parties.

VarSome offers a massive cross-referenced knowledge base of 140+ data sources, representing over 33 billion data points. We regularly update our databases to make sure the annotations and classifications we share are up-to-date.

VarSome.com provides automated germline variant classification based on the guidelines of the American College of Medical Genetics and Genomics (Richards et al. 2015). Each rule is explained, showing why it has or has not been triggered. Users can turn on and off rules to adjust for their own evidence and truly interrogate the classification.

VarSome Premium supports both germline and somatic classification, based on ACMG/AMP guidelines.

VarSome Clinical includes all Premium features and adds further flexibility. Users can apply ACMG-based classification to CNVs, import preferred transcripts, and integrate local population databases for customised annotation and classification.

You can search VarSome by HGVS nomenclature, rsID, gene name, transcript symbol, or genomic location. VarSome can also parse single lines from VCF files to find the variant they describe. The results are not limited to known variants; you can query any possible variant.

With VarSome Clinical, you can annotate entire VCF and FASTQ files and generate a clinical report for your NGS data.

With VarSome full-text search, you can query our knowledge base with plain text descriptions, making it easy to find what you're looking for. It allows you to perform targeted searches of the entire contents of VarSome, to find articles, diseases, phenotypes, genes, and more.

VarSome's API gives you direct access to our interpretation engine, combining rich data integration with fast, flexible annotation. Designed to work with your existing workflow, it simplifies variant analysis at scale, without the overhead of managing multiple data sources.