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Expert Support, Real Humans.
"VarSome has the best in silico one-stop-covers-it-all compilation of algorithms. We use it routinely for quick assessment of the pathogenicity of new variants."
"The prediction of pathogenicity of mutations, the integrated ClinVar, somatic databases, and the publication features are very useful."
"The ability to see why criteria have been ticked, as well as being able to change them and see how the prediction changes, makes interpreting the variants so much easier."
"One of the most helpful features was the integrated evidence from multiple databases, such as ClinVar, gnomAD, and COSMIC, which allowed us to quickly assess the potential clinical relevance of each variant."
Reinterpretation of Conflicting ClinVar BRCA1 Missense Variants Using VarSome and CanVIG-UK Gene-Specific Guidance - So et al. 2024.
Juvenile Paget disease with unique compound heterozygous sequence variants in the TNFRSF11B gene - Horackova et al. 2025.
Baseline levels and dynamic changes of cfDNA, tumor fraction and mutations to anticipate the clinical course of small cell lung cancer (SCLC) patients treated with first-line atezolizumab and chemotherapy: an hypothesis generating study (CATS/ML43257) - Pasello et al. 2025.
Want to read more? Click here for the list of publications.
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VarSome Clinical is a CE-IVDR Class C platform for clinical genetic testing workflows. It offers automated variant annotation and classification, supports germline and somatic pipelines, and offers various dynamic and algorithmic filters. Designed for diagnostics labs, it includes collaborative features, custom report templates, and deployment flexibility.

The VarSome API enables programmatic access to VarSome’s annotation engine. It supports high-throughput variant processing, returns ACMG/AMP-based classifications, and includes batch annotation and filtering tools. Designed for integration into bioinformatics pipelines, LIMS, or custom software, it offers scalable performance and flexible pricing.