--- title: VarSome Premium description: VarSome.com Premium is a subscription service allowing you to access additional 3rd party annotation data resources, features, and classifications without any delays. --- [Skip to content](https://landing.varsome.com/varsome-premium#main-content) [![VarSome logo white txts](https://landing.varsome.com/hs-fs/hubfs/VarSome%20logo%20white%20txts.png?width=160&height=40&name=VarSome%20logo%20white%20txts.png)](https://sso.varsome.com/) - Editions Show submenu for Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About Show submenu for About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources Show submenu for Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog Show submenu for Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) Open main navigation Close main navigation - Editions Show submenu for Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About Show submenu for About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources Show submenu for Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog Show submenu for Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) - [Sign In](https://varsome.com/) [Sign In](https://varsome.com/) ![premium-new2](https://landing.varsome.com/hubfs/varsome%20logos/premium-new2.png "premium-new2") THE HUMAN GENOMICS COMMUNITY VarSome Premium is a professional, community-driven platform for the interpretation of human genetic variants. It integrates a molecularDB made up of 150+ data sources, including population frequencies, clinical assertions, functional predictions, and somatic classifications. Contributions from our 600,000 users support data from knowledge bases like ClinVar, LOVD, PharmGKB, and OMIMⓇ. ![\_VPREM Graphics Lander](https://landing.varsome.com/hubfs/_VPREM%20Graphics%20Lander.png "_VPREM Graphics Lander") [![Get a Quote](https://no-cache.hubspot.com/cta/default/4384097/interactive-192832719112.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLJKu78g57ShNcJ%2FuQrHM3IFX%2FUY%2FELOe3RXpse1IUkBcZsZNNyb5PWaCLdhv8JQj2QKeAcTZU%2FXyXc4zTWZ6bNi2XFKJcsxjZxBThbBNzinV0sWX2QHHJc0PdQ7LA4AW5T1gTVam%2BkZKceiJjTnLosXz97y3IagjDCu1WKmZdw0psck4n3V2zgQ6mC9p0TAD3CctntQmVS%2FrWt94r3%2BEcHABegdZiD682%2B8nBUlQzAF5QKr2g%3D%3D&webInteractiveContentId=192832719112&portalId=4384097) [![Molecular DB](https://no-cache.hubspot.com/cta/default/4384097/interactive-192832719123.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLKSYoc0mj5xuMFKR7cXzlXG8cowd4AxYR2YpkhAA0vzirCFngGoOf01Ab%2BWTSDApKIUf6DjVU3KJ1YkaLjKog5dy0p%2BrWfSICpyNA3xidewO%2Fv6KobwJeIhCiwkS8xwana6cLix96cJZj2YVpj971KQWKhfPG2UWTzsyTnVb51C0iygQdeI5K0U9sKhM7jqXX2o0q3lcA%3D%3D&webInteractiveContentId=192832719123&portalId=4384097) ### **AI in VarSome: Generate report-ready narratives with VarSome Lighthouse** VarSome Lighthouse, an AI assistant, seamlessly summarizes data from over 150 integrated genomic databases into a **single, cohesive, report-ready narrative.** Unlike generic literature summarization tools, VarSome Lighthouse is built with **deterministic safety controls** and **strict clinical terminology guardrails** to ensure high scientific accuracy and **completely eliminate AI hallucinations** in data-scarce scenarios, so you can be confident that the output is **accurate** and based only on the **trusted sources** that already power the VarSome platform.   ![Icons for AI on landing page (3)](https://landing.varsome.com/hs-fs/hubfs/Icons%20for%20AI%20on%20landing%20page%20(3).png?width=2000&height=2000&name=Icons%20for%20AI%20on%20landing%20page%20(3).png "Icons for AI on landing page (3)") Included in Premium ## No More Waiting We apply query limits to keep VarSome responsive for the whole community. Free, registered users can run up to 30 queries per hour or 100 per day. **Premium subscribers get priority access,** so searches, annotations, and analysis run immediately, even during peak demand. ![3-4](https://landing.varsome.com/hubfs/3-4.png) [![Terms of Use](https://no-cache.hubspot.com/cta/default/4384097/interactive-193120087971.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLLsUnIBFCzFk%2FZzffDNs0N4%2BUY6pReVRR8sZ0g4poSiJmJTGbwQNAcuMflM7PUV1kPee5KbnEAQrmYvvIx51PEJKDN5%2FKaSPrc96yJ5yaEWgGPES%2FD6Ir%2BjDWUGhSGziXiY0xRdbscdinGUabYFVr%2FNPS88h7xsWy4lleIpw4JJmJ%2BA6vgNeL%2Bv8F6VzrJDf3DBOpmDm6WGdzdMCkHWg%2B6jOQ%3D%3D&webInteractiveContentId=193120087971&portalId=4384097) ## Access Premium Databases **Access the full VarSome knowledge base with additional data sources, including:** AACT Clinical Trials from clinicaltrials.gov; PharmGKB; COSMIC (Client License required); LOVD; Pharmacogenomic Biomarkers (FDA); SpliceVarDB; Clinical Pharmacogenetics Implementation Consortium (CPIC); OncoKB™; OMIMⓇ and more. ![1-Jul-17-2025-07-17-58-6572-AM](https://landing.varsome.com/hubfs/1-Jul-17-2025-07-17-58-6572-AM.png) [![See the Full List](https://no-cache.hubspot.com/cta/default/4384097/interactive-192832719459.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLLEslNqf37SLSCJvFjD4EZ3UUzTqO38ye8kJGxw9XPLgS4SXSWEz2yshvgXiG3NGQbBvlkAuxAF2cbGUaJD0yMcofN6iKb0%2Fj7lHinMpBlaVVNahaY%2FAFcFeTUTs6AW1kOpAA%2FV06YuqjNwTrEcRXqCss3L5C5TJSQIHVxinsp1wR1UZNhWUlnJUjlOwEvYHyZ5pNWtVQ%3D%3D&webInteractiveContentId=192832719459&portalId=4384097) ## Somatic Variant Interpretation Activate the built-in somatic classifier, based on AMP/ASCO/CAP guidelines. **Each somatic variant returns an automatic tier verdict plus rule-by-rule evidence.** You get a reproducible call for somatic workflows without extra software. ![2-Jul-17-2025-07-31-56-2298-AM](https://landing.varsome.com/hubfs/2-Jul-17-2025-07-31-56-2298-AM.png) [![Classifiers](https://no-cache.hubspot.com/cta/default/4384097/interactive-193120087985.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLK%2BdK8YDQRMbwFRWHTkpOhTcKY5ut92ss8IOodijmnm77BghejIEjNvsNwHsd%2BqeHmJwSOp1rs3finnw2BFDY6n0R8SoXo6XhgLQYw4aK8YJTCtiNM%2BcqS9ebZ8Kfag5ucwwvyCrru9zQWlMMt8O%2BKzRWb0izBgn%2FtRaCKDa0ftbW6%2Fx7RnlS6k0GHh27Seh5QYG9DdBFLhTI2yAWx7A0zMvIMGYlLvaKt4pJ2mm8GUBWS24siaE01sgiYhaz87&webInteractiveContentId=193120087985&portalId=4384097) Why VarSome? ![kb1](https://landing.varsome.com/hubfs/kb1.png) ## Our Variant Knowledge Base. VarSome is powered by our extensive variant knowledge base of 150+ data sources, including ClinVar, gnomAD, DECIPHER, OncoKB™, and COSMIC, to support evidence-based variant classification and confident clinical reporting. It combines live literature links with in silico predictions for SNVs, indels, CNVs, SVs, and repeat expansions to display the relevant data in one workspace, right at your fingertips. ![commnity1](https://landing.varsome.com/hubfs/commnity1.png) ## Join Our Global Community. VarSome’s powerful knowledge base is supported by our expert variant curation team and a 500 000 user global community of clinicians, researchers, and bioinformaticians in over 150 countries, sharing real-time variant data, contributing insights, and helping one another interpret complex cases. ![support](https://landing.varsome.com/hubfs/support.png) ## Expert Support, Real Humans. Get answers from people who understand clinical genomics. Our support team is made up of experts who speak your language. No chatbots. No Scripts. Just timely support, from real people, when you need it. Don't Take Our Word For It See what others have to say! > "VarSome has the best *in silico* one-stop-covers-it-all compilation of algorithms. We use it routinely for quick assessment of the pathogenicity of new variants." > > > > ![headshot\_Anna Dobretsova\_AMP (1)](https://landing.varsome.com/hs-fs/hubfs/headshot_Anna%20Dobretsova_AMP%20(1).jpg?width=60&height=64&name=headshot_Anna%20Dobretsova_AMP%20(1).jpg) > > Anna Dobretsova, Manager, Dept. of Molecular Diagnostics, Northside Hospital > "The prediction of pathogenicity of mutations, the integrated ClinVar, somatic databases, and the publication features are very useful." > > > > ![Maria-Mag Georgescu Headshot](https://landing.varsome.com/hs-fs/hubfs/Maria-Mag%20Georgescu%20Headshot.png?width=60&height=60&name=Maria-Mag%20Georgescu%20Headshot.png) > > Maria-Magdalena Georgescu, Medical Director, NeuroMarkers > "The ability to see why criteria have been ticked, as well as being able to change them and see how the prediction changes, makes interpreting the variants so much easier." > > ![N.routledge](https://landing.varsome.com/hs-fs/hubfs/N.routledge.png?width=60&height=60&name=N.routledge.png) > > Nathan Routledge, University College London > "One of the most helpful features was the integrated evidence from multiple databases, such as ClinVar, gnomAD, and COSMIC, which allowed us to quickly assess the potential clinical relevance of each variant." > > ![PR (1)](https://landing.varsome.com/hs-fs/hubfs/PR%20%20(1).png?width=60&height=60&name=PR%20%20(1).png) > > Giulia Pigato, Researcher, Veneto Institute of Oncology IOV, IRCCS Mentioned 5000+ Times in Literature Here are a few of our favorites ## Reinterpretation of Conflicting ClinVar BRCA1 Missense Variants Using VarSome and CanVIG-UK Gene-Specific Guidance - [So et al. 2024.](https://doi.org/10.3390/diagnostics14242821) ## Juvenile Paget disease with unique compound heterozygous sequence variants in the TNFRSF11B gene - [Horackova et al. 2025.](https://doi.org/10.1186/s13023-025-03804-2) ## Baseline levels and dynamic changes of cfDNA, tumor fraction and mutations to anticipate the clinical course of small cell lung cancer (SCLC) patients treated with first-line atezolizumab and chemotherapy: an hypothesis generating study (CATS/ML43257) - [Pasello et al. 2025.](https://doi.org/10.1186/s13046-025-03434-3) ## Want to read more? [Click here](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=%22varsome%22&oq=%22) for the list of publications. ## **Memberships & Partnerships** ##### TRUSTED BY CLINICAL LABS WORLDWIDE ![Diagnostica Longwood](https://landing.varsome.com/hs-fs/hubfs/dlongwood.png?width=200&height=39&name=dlongwood.png) ![IntegraGen](https://landing.varsome.com/hs-fs/hubfs/Logo_IntegraGen_OncoDNA-Group-CY.png?width=2000&name=Logo_IntegraGen_OncoDNA-Group-CY.png) ![partners\_biocat](https://landing.varsome.com/hs-fs/hubfs/partners_biocat.jpg?width=250&height=200&name=partners_biocat.jpg) ![Triolab-logo](https://landing.varsome.com/hs-fs/hubfs/Triolab-logo.webp?width=385&height=50&name=Triolab-logo.webp) ![4bases](https://landing.varsome.com/hs-fs/hubfs/4bases.jpg?width=233&height=90&name=4bases.jpg) ![GenCell](https://landing.varsome.com/hs-fs/hubfs/GenCell.jpg?width=249&height=196&name=GenCell.jpg) ![shiva](https://landing.varsome.com/hs-fs/hubfs/shiva.jpg?width=202&height=88&name=shiva.jpg) ![sial](https://landing.varsome.com/hs-fs/hubfs/sial.jpg?width=207&height=76&name=sial.jpg) ![partners\_biogene](https://landing.varsome.com/hs-fs/hubfs/partners_biogene.jpg?width=250&height=200&name=partners_biogene.jpg) ![partners\_varelas](https://landing.varsome.com/hs-fs/hubfs/partners_varelas.jpg?width=250&height=200&name=partners_varelas.jpg) ![partners\_evolve](https://landing.varsome.com/hs-fs/hubfs/partners_evolve.jpg?width=250&height=200&name=partners_evolve.jpg) ![elta-logo](https://landing.varsome.com/hs-fs/hubfs/elta-logo.png?width=229&height=183&name=elta-logo.png) ![medist-solutions-logo-777x250](https://landing.varsome.com/hs-fs/hubfs/medist-solutions-logo-777x250.png?width=400&height=129&name=medist-solutions-logo-777x250.png) ![partners\_danyel](https://landing.varsome.com/hs-fs/hubfs/partners_danyel.jpg?width=250&height=200&name=partners_danyel.jpg) ![partners\_thunderbio](https://landing.varsome.com/hs-fs/hubfs/partners_thunderbio.jpg?width=250&height=200&name=partners_thunderbio.jpg) ![sciencewerke](https://landing.varsome.com/hs-fs/hubfs/sciencewerke.png?width=300&height=123&name=sciencewerke.png) ![Flash -china](https://landing.varsome.com/hs-fs/hubfs/Flash%20-china.webp?width=244&height=100&name=Flash%20-china.webp) ![Logo LongSeq](https://landing.varsome.com/hs-fs/hubfs/Logo%20LongSeq.jpg?width=200&height=113&name=Logo%20LongSeq.jpg) ![partners\_hpst](https://landing.varsome.com/hs-fs/hubfs/partners_hpst.jpg?width=250&height=200&name=partners_hpst.jpg) ![partners\_perlan](https://landing.varsome.com/hs-fs/hubfs/partners_perlan.jpg?width=250&height=200&name=partners_perlan.jpg) ![Alpha Chrom](https://landing.varsome.com/hs-fs/hubfs/images.png?width=150&height=94&name=images.png) Interested in Our Other Solutions? ![VCLIN Dark 400x50 C](https://landing.varsome.com/hs-fs/hubfs/VCLIN%20Dark%20400x50%20C.png?width=360&height=45&name=VCLIN%20Dark%20400x50%20C.png "VCLIN Dark 400x50 C") VarSome Clinical is a CE-IVDR Class C platform for clinical genetic testing workflows. It offers automated variant annotation and classification, supports germline and somatic pipelines, and offers various dynamic and algorithmic filters. Designed for diagnostics labs, it includes collaborative features, custom report templates, and deployment flexibility. [![Start Analyzing](https://no-cache.hubspot.com/cta/default/4384097/interactive-193382885292.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLL4PAd5n8kVa6siiAWlq4h2fvwml2gt9q3iARy9KYP3JFzaChtrJcL6O0hllooxo%2BSfzPcTC%2BzJqyA5itGaw6L08OPWIo17SKXjRBLK9yFKOaVkA2gQGYKbJwIilRMIGDEprI0Pzo8Cp%2B1DlcSIdDdNqMyKi91sM9YMQCESUXp1PrOUTW7WCsDEVYAXs2%2Bb6g%2FTjSxQPegwLs5H5p%2Bv1yC1Iw%3D%3D&webInteractiveContentId=193382885292&portalId=4384097) ![3-Jul-24-2025-04-54-54-7356-PM](https://landing.varsome.com/hs-fs/hubfs/3-Jul-24-2025-04-54-54-7356-PM.png?width=400&height=50&name=3-Jul-24-2025-04-54-54-7356-PM.png "3-Jul-24-2025-04-54-54-7356-PM") The VarSome API enables programmatic access to VarSome’s annotation engine. It supports high-throughput variant processing, returns ACMG/AMP-based classifications, and includes batch annotation and filtering tools. Designed for integration into bioinformatics pipelines, LIMS, or custom software, it offers scalable performance and flexible pricing. 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