--- title: VarSome Clinical Oncology description: Interpret somatic variants with confidence using VarSome Clinical; AMP-tiered classification, OncoKB integration, and custom reporting in a CE-IVDR certified platform. --- [Skip to content](https://landing.varsome.com/oncology#main-content) [![VarSome logo white txts](https://landing.varsome.com/hs-fs/hubfs/VarSome%20logo%20white%20txts.png?width=160&height=40&name=VarSome%20logo%20white%20txts.png)](https://sso.varsome.com/) - Editions Show submenu for Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About Show submenu for About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources Show submenu for Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog Show submenu for Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) Open main navigation Close main navigation - Editions Show submenu for Editions - [VarSome.com](https://landing.varsome.com/varsome) - [VarSome Clinical](https://landing.varsome.com/varsome-clinical) - [VarSome Premium](https://landing.varsome.com/varsome-premium) - [VarSome API](https://landing.varsome.com/varsome-api) - [VarSome Insights](https://landing.varsome.com/varsome-insights) - About Show submenu for About - [The Company](https://saphetor.com/) - [Contact Us](https://landing.varsome.com/contact) - [Distributors](https://landing.varsome.com/distributors) - [Become a Partner](https://landing.varsome.com/become-varsome-partner) - [Community](https://varsome.com/community-contributions/) - [Cite VarSome!](https://landing.varsome.com/citations) - Resources Show submenu for Resources - [Datasources](https://varsome.com/datasources/) - [Germline Classification](https://varsome.com/about/resources/germline-implementation/) - [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) - [CNV Classification](https://varsome.com/about/resources/sv-implementation/) - [Help Center](https://docs.varsome.com/) - [Library](https://landing.varsome.com/whitepapers) - [IVDR](https://landing.varsome.com/ivdr-whitepaper) - [Legal & Compliance](https://docs.varsome.com/en/legal-compliance) - Blog Show submenu for Blog - [Platform Updates](https://updates.varsome.com/en) - [Company News](https://news.varsome.com/en) - [VarSome Annotated](https://blog.varsome.com/annotated) - [Sign In](https://varsome.com/) [Sign In](https://varsome.com/) ![VCLIN 800x100](https://landing.varsome.com/hs-fs/hubfs/VCLIN%20800x100.png?width=600&height=75&name=VCLIN%20800x100.png "VCLIN 800x100") Oncology ## VarSome Clinical brings all variant types into one workspace, combining AMP-based classification, FDA-recognized OncoKB™ annotations, and real-time therapy insights from our massive variant knowledge base, in a CE-IVDR certified platform. [![Book a Demo](https://no-cache.hubspot.com/cta/default/4384097/interactive-192068292692.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLIQLHtGc5H8A7wDY6ToPjxvk3h0IkfEb9UtN4YXhe30l6n1tDQOzety79%2FexvuQ0AU4twahBYuWwT17IKYIsLUEEFyv3x4rin%2FOC89gS5NiCaXoCRp05rBTkWfxnOFwxsiKwnUkSSVlKODoEUchrcMHhL6QObv5pxRDgi8%2FXdYgExMXtk35U1pMcqAYdQrwn8sECjPX3wGTlF1E3xSHAndu6xoCVL%2BykPPnFkLN4kK2bsK0YyQ%3D&webInteractiveContentId=192068292692&portalId=4384097) Somatic Analysis with VarSome Clinical ## Somatic Variant Interpretation Annotation and interpretation of SNVs, indels, CNVs, SVs, and repeat expansions is supported in a unified framework. **Classifications are evidence-based and aligned with AMP/ASCO/CAP guidelines,** ensuring consistent and transparent evaluation of clinical significance. **Integrated datasets and curated knowledge sources** keep results anchored in the latest scientific and clinical understanding. ## Actionability and Clinical Relevance **Annotations draw from oncology-focused resources such as OncoKB™, CIViC, PharmGKB, and other curated datasets.** Variants are linked to **drug associations, predictive biomarkers, and clinical trial opportunities,** helping connect molecular findings to therapeutic options and research directions. ## Tumor-Specific Context Support for mutational signatures, **Tumor Mutational Burden (TMB), and Microsatellite Instability (MSI)** provides insight into key biomarkers that guide immunotherapy decisions. Gene- and cancer type-specific annotations further **tailor** **variant interpretation to the biological and clinical context of each tumor**, ensuring results are both precise and clinically relevant. ## Transparent Evidence Framework **Each classification is backed by traceable evidence, including direct links to the underlying literature and databases**. Users can review how each rule was applied and **toggle individual criteria on or off, providing full control** to interrogate the classification and understand the reasoning behind it.  ## Clinical Reporting Support **At-a-glance summaries help highlight relevant findings,** ready to be included in clinical reports. **Evidence is organized into therapeutic, prognostic, and diagnostic categories** to support clear communication of molecular results.  **Reports can be exported as PDF or JSON** to ensure flexibility for both clinical documentation and downstream analysis. ## Scalability for Precision Oncology **Built to handle both individual tumor cases and large cohort studies,** VarSome adapts to the scale of each project without compromising consistency. Full API support enables seamless **integration into existing oncology workflows** for reproducible and efficient analysis across research and clinical findings. TMB & MSI Biomarkers ![](https://landing.varsome.com/hubfs/Screenshot%202026-05-25%20at%2012.27.26%20PM.png) **VarSome Clinical enables accurate TMB and MSI assessment from tumor-only sequencing data, so no matched normal is required.** TMB is estimated from WES or Agilent CGP panels with ≥50x coverage, with variants filtered to remove germline noise. **Both total and non-synonymous mutation rates** are reported, with samples classified as TMB-high (≥10 mut/Mb) or TMB-low. MSI status is determined from FASTQ data using **a TCGA-derived baseline and cancer-specific thresholds**, with results reported as MSI-High or Not Detected. Both workflows are **optimized for clinical interpretation** and integrate seamlessly into the somatic analysis pipeline. [![Read More](https://no-cache.hubspot.com/cta/default/4384097/interactive-193126467860.png)](https://landing.varsome.com/hs/cta/wi/redirect?encryptedPayload=AVxigLLVAchTvwu8U9VJOeaMis3KJnwLwMtovDkTcNLn2LrrA5AoDz6FNMaTkKJwWkqQJLeXuwVn8qZ7yDLRNJc9XpR3THeg3iiUOZA%2FapGyiYky1Wbf63beKZSLAjIwegcgFBina813LhzmzWauRULekrhrkehJ%2FWaGeQR0387oHqoTpkiT%2F6koosWkaud1epbXyV8h64pdEI%2B5lgfQ6oboxlAfBbMSGr8gB8%2FLu4Mz2xU%3D&webInteractiveContentId=193126467860&portalId=4384097) ## Why VarSome Clinical? ![kb1](https://landing.varsome.com/hubfs/kb1.png) ## Our Variant Knowledge Base. VarSome Clinical is powered by our extensive variant knowledgebase, including ClinVar, gnomAD, DECIPHER, OncoKB™, CKB, and COSMIC, to support evidence-based variant classification and confident clinical reporting. It combines live literature links with in silico predictions for SNVs, indels, CNVs, SVs, and repeat expansions to display the relevant data in one workspace, right at your fingertips. ![commnity1](https://landing.varsome.com/hubfs/commnity1.png) ## Join Our Global Community. VarSome’s powerful knowledge base is supported by our expert variant curation team and a 500'000 user global community of clinicians, researchers, and bioinformaticians in over 150 countries, sharing real-time variant data, contributing insights, and helping one another interpret complex cases. ![eye1](https://landing.varsome.com/hubfs/eye1.png) ## All Variants, One Workspace. View SNVs, indels, CNVs, SVs, and repeat expansions together in our Sample Viewer. VarSome Clinical brings these variant types into a single, streamlined interface so you can explore genomic context, assess overlaps, and review sample-level data in one intuitive genomic browser. ![support](https://landing.varsome.com/hubfs/support.png) ## Expert Support, Real Humans. Get answers from people who understand clinical genomics. Our support team is made up of experts who speak your language. No chatbots. No Scripts. Just timely support, from real people, when you need it. [![VarSome logo white txts](https://landing.varsome.com/hs-fs/hubfs/VarSome%20logo%20white%20txts.png?width=160&height=40&name=VarSome%20logo%20white%20txts.png "VarSome logo white txts")](http://varsome.com) Saphetor SA EPFL Innovation Park - I, 1015 Lausanne, Switzerland facebook-f icon linkedin-in icon Twitter icon instagram icon VARSOME SUITE [Varsome.com](https://landing.varsome.com/varsome) [Varsome Premium](https://landing.varsome.com/varsome-premium) [VarSome Clinical](https://landing.varsome.com/varsome-clinical) [VarSome API](https://landing.varsome.com/varsome-api) [VarSome insights](https://landing.varsome.com/varsome-insights)   RESOURCES [Query Examples](https://varsome.com/about/resources/examples/) [Germline Classification](https://varsome.com/about/resources/germline-implementation/) [Somatic Classification](https://varsome.com/about/resources/somatic-implementation/) [Whitepapers & other resources](https://varsome.com/library/) [Help Center](https://docs.varsome.com/en) [Cite VarSome](https://varsome.com/about/general/varsome-citations/)   THE COMPANY [About Saphetor SA](https://saphetor.com/) [News](https://news.varsome.com/en) [Distributors](https://landing.varsome.com/distributors) [Contact](https://landing.varsome.com/contact)   LEGAL [Terms of Use](https://varsome.com/information/legal/terms/) [Privacy Policy](https://varsome.com/information/legal/privacy/) [Information Security](https://varsome.com/information/legal/information-security/)   SYSTEM STATUS [System status](https://status.saphetor.com/) ## The VarSome Suite is brought to you by [Saphetor SA](https://saphetor.com/) ©2025 Saphetor SA - All Rights Reserved ```json { "@context" : "https://schema.org", "@type" : "VideoObject", "contentUrl" : "https://stream.mux.com/pMyPkng00aRpLVw7pcF5yggYzXBlTv2bIhr9oDKErRKo/capped-1080p.mp4", "dateModified" : "2026-03-09T15:34:37.446Z", "duration" : "PT2M31.802S", "height" : 1080, "name" : "Oncology 2025", "thumbnailUrl" : "https://4384097.fs1.hubspotusercontent-na1.net/hubfs/4384097/Videos-Demos-2025/Oncology%202025.mp4/medium.jpg", "uploadDate" : "2025-05-22T07:46:28.063Z", "width" : 1920 } ```