Get germline and somatic classifications returned with full transparency, including the criteria triggered and supporting literature references. The API automates the process but does not remove your control. You decide how results are reviewed, interpreted, and used in your workflow.

VarSome API supports the annotation of SNVs, CNVs, structural variants, and repeat expansions. It works with data from long-read platforms such as PacBio and Oxford Nanopore Technologies, enabling the detection of variants in non-coding or structurally complex regions that may be missed by standard short-read sequencing.

The VarSome API is available in three environments, each designed for different use cases and stability requirements.

The Stable environment is a frozen version with updates released quarterly, suitable for production use. This environment offers high data quality and consistency, but may lag behind the latest updates by up to six months. It is unthrottled and included in all subscriber plans.

The Live environment provides access to the most up-to-date data, including recent user community contributions. It is updated monthly or at our discretion and is ideal for exploratory or flexible use. Like Stable, it is unthrottled and available to subscribers.

The Staging environment mirrors the upcoming Stable release and is intended for testing and validation. It is frozen at least four weeks before a Stable release to allow for compatibility testing. During this time, it may still receive updates if bugs are found. After release, Staging is updated again to reflect Live or internal development versions. Access is throttled and limited to subscribers.

Choosing the right environment helps ensure your integration remains reliable and predictable.

Pricing scales with usage, and you only pay for the data you request. To keep costs low, you can filter by allele frequency, limit to coding or splice-site variants, or select only the annotations you need. High-volume users benefit from lower rates, while monthly caps and dedicated instances are also available

From single-sample clinical interpretation to large-scale cohort annotation, the API scales to match your workload. Submit up to 200 variants in a single request and configure it for high-throughput use with batch processing, smart filtering, and usage cap controls.

Use VarSome’s API to apply consistent interpretation logic across your lab or organisation. Whether centralised or distributed, it ensures reproducible results, alignment with ACMG and AMP guidelines, and up-to-date classification rules in every request.